[1]周诚,沈天皓,蒋霆辉,等.125I粒子联合动脉灌注化疗对中晚期胰腺癌患者的临床疗效观察 [J].介入放射学杂志,2024,33(08):878-884.
　ZHOU Cheng,SHEN Tianhao,JIANG Tinghui,et al.Clinical effect of 125I seeds implantation combined with arterial infusion chemotherapy for patients with advanced pancreatic cancer[J].journal interventional radiology,2024,33(08):878-884.
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125I粒子联合动脉灌注化疗对中晚期胰腺癌患者的临床疗效观察
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
33
期数:
2024年08
页码:
878-884
栏目:
临床研究
出版日期:
2024-08-12

文章信息/Info

Title:
Clinical effect of 125I seeds implantation combined with arterial infusion chemotherapy for patients with advanced pancreatic cancer
作者:
周诚; 沈天皓; 蒋霆辉; 俞雪; 刘艳
Author(s):
ZHOU Cheng; SHEN Tianhao; JIANG Tinghui; YU Xue; LIU Yan.
Department of Interventional Oncology，Affiliated Putuo Hospital，Shanghai University of Traditional Chinese Medicine，Shanghai 200062，China
关键词:
【关键词】胰腺癌;  125I粒子;  动脉灌注化疗
文献标志码:
A
摘要:
【摘要】目的评价125I粒子联合动脉灌注化疗（transcatheter arterial infusion，TAI）对中晚期胰腺癌（pancreaticcarcinoma，PC）的临床疗效。方法将符合入组的76例患者采用信封封藏法随机分为观察组、对照组。最终纳入67例，观察组为125I粒子联合TAI（31例），对照组为TAI（36例），治疗3个疗程后比较两组的临床疗效、疼痛评分、梗阻性黄疸（obstructive jaundice，OJ）发生率及生存期。结果观察组客观缓解率（ORR）为48.4%，对照组为25.0%，差异有统计学意义（P＜0.05）；观察组疾病控制率（DCR）为83.9%，对照组为66.7%，差异无统计学意义（P＞0.05）。两组患者术后1、3个月的疼痛评分均较前下降（P＜0.05），但观察组疼痛评分下降明显高于对照组（P＜0.05）。观察组、对照组疼痛缓解率分别为23.06%、13.4%，差异有统计学意义（P=0.0252）；观察组、对照组OJ发生率分别为19.4%、50.0%，差异有统计学意义（P＜0.05）；观察组、对照组患者中位生存期分别为7.9个月、5.1个月，差异有统计学意义（P＜0.05）。两组患者术后1、3个月CA199水平均有所下降，差异有统计学意义（P＜0.05）。两组患者恶心呕吐、腹泻和白细胞减少等不良反应发生率比较，差异无统计学意义（P＞0.05）。结论125I粒子联合TAI可以有效缓解中晚期PC癌痛，延长生存时间，且安全性良好，值得临床推广。

参考文献/References:

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备注/Memo

备注/Memo:
 (收稿日期:2023-08-16)
(本文编辑:茹 实)
更新日期/Last Update: 2024-08-08