[1]陈天佑,袁 敏,周 粟,等.3.0T动态增强磁共振灌注成像对小肝癌射频消融疗效评估的价值研究[J].介入放射学杂志,2022,31(02):154-159.
 CHEN Tianyou,YUAN Min,ZHOU Su,et al.The application of 3.0T DCE-MRI in evaluating curative effect of radiofrequency ablation for small hepatocellular carcinoma: a clinical study[J].journal interventional radiology,2022,31(02):154-159.
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3.0T动态增强磁共振灌注成像对小肝癌射频消融疗效评估的价值研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
31
期数:
2022年02
页码:
154-159
栏目:
非血管介入
出版日期:
2022-02-25

文章信息/Info

Title:
The application of 3.0T DCE-MRI in evaluating curative effect of radiofrequency ablation for small hepatocellular carcinoma: a clinical study
作者:
陈天佑 袁 敏 周 粟 杨柏帅 侯毅斌 李清涛
Author(s):
CHEN Tianyou YUAN Min ZHOU Su YANG Boshuai HOU Yibin LI Qingtao.
Department of Interventional Radiology, Affiliated Shanghai Public Health Clinical Center of Fudan University, Shanghai 201508, China
关键词:
【关键词】 原发性肝癌 功能磁共振成像 射频消融
文献标志码:
A
摘要:
【摘要】 目的 探讨动态增强磁共振灌注成像(DCE-MRI)定量评估小肝癌射频消融(RFA)疗效的预测价值。方法 选取2016年3月至2020年6月初诊单发小肝癌病灶58例。采用Philips 3.0T MR对全部入组患者于治疗前行MR常规T1WI、T2WI、DCE-MRI序列扫描,分别测得肿瘤最大层面的各扫描序列定量参数-包括血管通透性常数(transfer constant,Ktrans)、血管外细胞外间隙容积百分比(volume of extravascular extraeellular space per unit volume of tissue,Ve)及血液回流常数(the rate constant,Kep)值。病理切片通过免疫组织化学方法检测微血管密度。根据mRECIST标准进行随访,将病例分为稳定组和进展组。比较两组RFA治疗前各定量指标的差异,计量资料组间比较采用独立样本t检验。用Pearson相关检验分析两组患者DCE-MRI各灌注参数与微血管密度(MVD)之间的相关性。结果 稳定组以及进展组初始病灶大小差异有统计学意义,稳定组较进展组的病灶更小。消融前稳定组Ktrans值(0.343±0.074) min-1、Kep值(0.904±0.153) min-1及MVD值(49.000±5.518)均较进展组低,且差异具有统计学意义。两组患者治疗前DCE-MRI各参数值与MVD的相关分析显示Ktrans值、Ve值与MVD呈正相关,相关系数分别为0.677、0.334 。结论 动态增强DCE-MRI灌注分析参数Ktrans、Kep均能有效预测肝癌RFA疗效,且在一定程度上可对肿瘤的微血管密度进行检测。

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更新日期/Last Update: 2022-02-21