[1]王勇,陆建,陈荔,等.125I粒子气管支架与普通气管支架治疗食管癌所致恶性气道梗阻的对照研究[J].介入放射学杂志,2020,29(02):159-164.
 WANG Yong,LU Jian,CHEN Li,et al.Tracheal stent loaded with 125I seeds versus conventional tracheal stent for the treatment of malignant airway obstruction caused by esophageal cancer: a control study[J].journal interventional radiology,2020,29(02):159-164.
点击复制

125I粒子气管支架与普通气管支架治疗食管癌所致恶性气道梗阻的对照研究()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年02
页码:
159-164
栏目:
非血管介入
出版日期:
2020-03-14

文章信息/Info

Title:
Tracheal stent loaded with 125I seeds versus conventional tracheal stent for the treatment of malignant airway obstruction caused by esophageal cancer: a control study
作者:
王勇陆建陈荔朱光宇郭金和
Author(s):
WANG Yong LU Jian CHEN Li ZHU Guangyu GUO Jinhe.
Department of Intervention and Vascular Surgery, Affiliated Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province 210009, China
关键词:
【关键词】 恶性气道狭窄支架碘粒子
文献标志码:
A
摘要:
【摘要】 目的?比较125I粒子气管支架与普通气管支架治疗食管癌所致恶性气道梗阻的有效性。方法?回顾性分析2014年1月至2018年1月食管癌所致恶性气道狭窄行支架置入的患者46例,其中接受125I粒子气管支架置入24例,接受普通气管支架置入22例。主要分析指标为总生存时间(OS),次要指标为技术成功率、气道狭窄程度、症状缓解、安全性。结果?中位随访时间155 d(全距,15~270 d)。
两组支架置入的技术成功率均为100%。支架置入后,125I粒子支架组患者的平均狭窄程度由术前3.00下降到0.95,普通支架组由术前3.13下降到0.96(两组手术前后比较,P<0.001)。两组患者术后呼吸困难症状均得到明显缓解。125I粒子支架组的患者mOS明显长于普通支架组(156 d比103 d,P=0.005)。两组的并发症发生率无显著差异(20.5%比27.3%,P=0.374)。结论?125I粒子气管支架置入治疗食管恶性气道狭窄技术可行、安全,相较于普通气管支架能延长患者总生存时间。

参考文献/References:

[1] Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014[J]. Chin J Cancer Res, 2018, 30: 1-12.
[2] Ernst A, Simoff M, Ost D, et al. Prospective risk-adjusted morbidity and mortality outcome analysis after therapeutic bronchoscopic procedures: results of a multi-institutional outcomes database[J]. Chest, 2008, 134: 514-519.
[3] Ost DE, Ernst A, Grosu HB, et al. Complications following therapeutic bronchoscopy for malignant central airway obstruction: results of the AQuIRE registry[J]. Chest, 2015, 148: 450-471.
[4] Ost DE, Ernst A, Grosu HB, et al. Therapeutic bronchoscopy for malignant central airway obstruction success rates and impact on dyspnea and quality of life[J]. Chest, 2015, 148: 1282-1298.
[5] Lagergren J, Smyth E, Cunningham D, et al. Oesophageal cancer[J]. Lancet, 2017, 390: 2383-2396.
[6] Freitag L, Gordes M, Zarogoulidis P, et al. Towards individualized tracheobronchial stents: technical, practical and legal considerations [J]. Respiration, 2017, 94: 442-456.
[7] Miyazawa T, Yamakido M, Ikeda S, et al. Implantation of ultraflex nitinol stents in malignant tracheobronchial stenoses[J]. Chest, 2000, 118: 959-965.
[8] Breitenbucher A, Chhajed PN, Brutsche MH, et al. Long-term follow-up and survival after Ultraflex stent insertion in the management of complex malignant airway stenoses[J]. Respiration, 2008, 75: 443-449.
[9] Profili S, Manca A, Feo CF, et al. Palliative airway stenting performed under radiological guidance and local anesthesia[J]. Cardiovasc Intervent Radiol, 2006, 30: 74-78.
[10] Kim JH, Shin JH, Song HY, et al. Palliative treatment of inoperable malignant tracheobronchial obstruction: temporary stenting combined with radiation therapy and/or chemotherapy[J]. AJR Am J Roentgenol, 2009, 193: W38-W42.
[11] Rochet N, Hauswald H, Schmaus M, et al. Safety and efficacy of thoracic external beam radiotherapy after airway stenting in malignant airway obstruction[J]. Int J Radiat Oncol Biol Phys, 2012, 83: e129-e135.
[12] Saji H, Furukawa K, Tsutsui H, et al. Outcomes of airway stenting for advanced lung cancer with central airway obstruction[J]. Interact Cardiovasc Thorac Surg, 2010, 11: 425-428.
[13] Guo JH, Teng GJ, Zhu GY, et al. Self-expandable esophageal stent loaded with 125I seeds: initial experience in patients with advanced esophageal cancer[J]. Radiology, 2008, 247: 574-581.
[14] Zhu HD, Guo JH, Zhu GY, et al. A novel biliary stent loaded with 125I seeds in patients with malignant biliary obstruction: preliminary results versus a conventional biliary stent[J]. J Hepatol, 2012, 56: 1104-1111.
[15] Zhu HD, Guo JH, Mao AW, et al. Conventional stents versus stents loaded with 125iodine seeds for the treatment of unresectable oesophageal cancer: a multicentre, randomised phase 3 trial[J]. Lancet Oncol, 2014, 15: 612-619.
[16] Wang Y, Guo JH, Zhu GY, et al. A novel self-expandable, radioactive airway stent loaded with 125I seeds: a feasibility and safety study in healthy beagle dog[J]. Cardiovasc Intervent Radiol, 2017, 40: 1086-1093.
[17] Wang Y, Lu J, Guo JH, et al. A novel tracheobronchial stent loaded with 125I seeds in patients with malignant airway obstruction compared to a conventional stent: a prospective randomized controlled study[J]. EBioMedicine, 2018, 33:269-275.
[18] Vano E, Rosenstein M, Liniecki J, et al. ICRP publication 113.Education and training in radiological protection for diagnostic and interventional procedures[J]. Ann ICRP, 2009, 39: 7-68.
[19] Freitag L, Ernst A, Unger M, et al. A proposed classification system of central airway stenosis[J]. Eur Respir J, 2007, 30: 7-12.
[20] Celikoglu F, Celikoglu SI, Goldberg EP. Bronchoscopic intratumoral chemotherapy of lung cancer[J]. Lung Cancer, 2008, 61: 1-12.
[21] Rajeev P, Ezzat T, Slade M, et al. Tracheal stenting has minimal impact on survival in anaplastic thyroid carcinoma[J]. World J Surg, 2013, 37: 2589-2593.
[22] Lu J, Guo JH, Zhu HD, et al. Safety and efficacy of irradiation stent placement for malignant portal vein thrombus combined with transarterial chemoembolization for hepatocellular carcinoma: a single-center experience[J]. J Vasc Interv Radiol, 2017, 28: 786. e3-794. e3.
[23] Zhu HD, Guo JH, Huang M, et al. Irradiation stents vs. conventional metal stents for unresectable malignant biliary obstruction: a multicentre trial[J]. J Hepatol, 2018, 68:970-977.
[24] 魏?宁, 陈启鸿, 徐?浩, 等. 通气导管辅助下125I支架置入术治疗恶性气道狭窄24例[J]. 介入放射学杂志, 2017, 26:1118-1121.
[25] 赖光湖, 窦?娟, 吴小明, 等. 125I放射性粒子食管支架治疗进展期食管癌的生活质量评价[J].介入放射学杂志, 2018, 27:842-846.
[26] Gorden JA, Ernst A. Endoscopic management of central airway obstruction[J]. Semin Thorac Cardiovasc Surg, 2009, 21: 263-273.
[27] Saad CP, Murthy S, Krizmanich G, et al. Self-expandable metallic airway stents and flexible bronchoscopy: long-term outcomes analysis[J]. Chest, 2003, 124: 1993-1999.
[28] McDermott CE, Gengozian N. The effect of low exposure-rate gamma irradiation on T and B lymphocyte function in the mouse[J]. Int J Radiat Biol Relat Stud Phys Chem Med, 1980, 37: 415-428.
[29] Serhatlioglu S, Ogur E, Ozan AT, et al. Biochemical and immunological effects of ionizing radiation in radiology staff members[J]. Tani Girisim Radyol, 2004, 10: 97-102.
[30] Guo JH, Teng GJ, Zhu GY, et al. Self-expandable stent loaded with 125I seeds: feasibility and safety in a rabbit model[J]. Eur J Radiol, 2007, 61: 356-361.

相似文献/References:

[1]张鑫 刘建民 洪波 许奕 黄清海 张珑 赵文元 周晓平.多支架治疗颅内外动脉狭窄[J].介入放射学杂志,2003,(03):198.
[2]谢剑,李明华.颈动脉支架成形术的报道规范化讨论[J].介入放射学杂志,2005,(06):665.
 XIE Jian LI Ming-hua.Standardization of the reports for carotid artery stenting[J].journal interventional radiology,2005,(02):665.
[3]飞勇,丁莹莹,黄明,等.125I粒子支架治疗晚期食管癌的临床初步探讨[J].介入放射学杂志,2006,(01):45.
 FEI Yong,DING Ying-ying,HUANG Ming,et al.Clinical primary results on late esophageal cancer by self-expandable and 125I seed[J].journal interventional radiology,2006,(02):45.
[4]赵辉,倪才方.覆膜自膨式金属内支架治疗食管瘘[J].介入放射学杂志,2006,(02):112.
 ZHAO Hui,NI Cai-fang.Self-expanding covered stent for esophageal fistula[J].journal interventional radiology,2006,(02):112.
[5]周子奎,陈宝菊,林长平,等.食管支架植入术后并发症及相关因素的探讨[J].介入放射学杂志,2006,(02):114.
 ZHOU Zi-kui,CHEN Bao-ju,LIN Chang-ping.Study of the complications after esophageal stent placement and the correlative factors[J].journal interventional radiology,2006,(02):114.
[6]王峰,徐克.积极科学地开展管腔内支架的临床应用[J].介入放射学杂志,2006,(03):129.
 WANG Feng,XU Ke.Positively and reasonably clinical application of endoluminal stenting[J].journal interventional radiology,2006,(02):129.
[7]刘清欣,王建华,罗剑钧,等.肝癌致下腔静脉梗阻的内支架治疗[J].介入放射学杂志,2007,(03):168.
 LIU Qing-xin,WANG Jian-hua,LUO Jian-jun,et al.Stenting in malignant obstruction of inferior vena cava caused by hepatic carcinoma[J].journal interventional radiology,2007,(02):168.
[8]焦力群,李慎茂,李萌,等.支架成形术治疗颈动脉狭窄的脑血流定量评价[J].介入放射学杂志,2007,(05):295.
 JIAO Li-qun,LI Shen-mao,LI Meng,et al.Quantitative evaluation of cerebral blood flow by XeCT in stenting angioplasty for carotid artery stenosis[J].journal interventional radiology,2007,(02):295.
[9]萧毅,弓静,田建明,等.64层螺旋CT冠状动脉造影评价冠状动脉支架再狭窄[J].介入放射学杂志,2007,(05):312.
 XIAO Yi,GONG Jing,TIAN Jian-ming,et al.Evaluation of in-stent restenosis in coronary arteries with64multislice computed tomography[J].journal interventional radiology,2007,(02):312.
[10]朱凤水,李慎茂,缪中荣,等.急性椎基底动脉闭塞的介入治疗[J].介入放射学杂志,2007,(05):348.
 Interventional therapy for acute vertebrobasilar arterial occlusions ZHU Feng-shui,LI Shen-mao,MIAO Zhong-rong,et al.Interventional therapy for acute vertebrobasilar arterial occlusions[J].journal interventional radiology,2007,(02):348.

备注/Memo

备注/Memo:
(收稿日期:2019-03-11)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2020-03-13