[1]卢海燕,吕玲春,沈珈谊,等.氨基末端脑钠肽前体与冠状动脉造影后对比剂肾病相关性研究 [J].介入放射学杂志,2018,27(09):817-821.
 LU Haiyan,LV Lingchun,SHEN Jiayi,et al.Correlation between N- terminal pro- brain natriuretic peptide levels and contrast- induced nephropathy in patients after receiving coronary angiography: a clinical study[J].journal interventional radiology,2018,27(09):817-821.
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氨基末端脑钠肽前体与冠状动脉造影后对比剂肾病相关性研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
27
期数:
2018年09期
页码:
817-821
栏目:
心脏介入
出版日期:
2018-09-25

文章信息/Info

Title:
Correlation between N- terminal pro- brain natriuretic peptide levels and contrast- induced nephropathy in patients after receiving coronary angiography: a clinical study
作者:
卢海燕 吕玲春 沈珈谊 徐 剑 吴小燕 韦铁民 纪建松
Author(s):
LU Haiyan LV Lingchun SHEN Jiayi XU Jian WU Xiaoyan WEI Tiemin JI Jiansong
Electrocardiography Room, Lishui Municipal Central Hospital, Lishui, Zhejiang Province 323000, China
关键词:
【关键词】 N氨基末端脑钠肽前体 冠状动脉造影 对比剂肾病
文献标志码:
A
摘要:
【摘要】 目的 探讨冠状动脉造影(CAG)前血清N氨基末端脑钠肽前体(NT- proBNP)水平是否是一独立预测CAG后发展为对比剂肾病(CIN)的可靠有用的生物标志物。方法 纳入2014年6月至12月收治的228例急性胸痛患者为研究对象,CAG前24 h内检测血清NT- proBNP、血清肌酐(SCr)、胱抑素(Cys)C、血尿素氮(BUN)、尿酸(UA),CAG后24、48、72 h检测NT- proBNP、SCr、BUN、UA。根据肾脏疾病膳食改良(MDRD)公式计算肾小球滤过率估计值(eGFR)。根据CAG后72 h内是否发生CIN,分为CIN组(n=36)和非CIN组(n=192)。采用受试者特征曲线(ROC)及Logistic回归分析,评价CAG前NT- proBNP对CIN预测价值。结果 CIN组、非CIN组CAG前NT- proBNP分别为(1 065.41±275.08) pg/mL、(533.02±489.32) pg/mL(P<0.001),NT- proBNP曲线下面积(AUC)为0.821(95%CI=0.768~0.875), CIN发生预测灵敏度为77.8%,特异度为78.0%。Logistic回归分析显示CAG前NT- proBNP是CIN发病危险因素,NT- proBNP升高患者CIN发病率比正常患者高2.42倍。Pearson 相关性分析显示CAG前NT- proBNP与CAG后SCr升高绝对值呈正相关(OR=0.17,P=0.01)。结论 CAG前NT- proBNP是独立预测急性胸痛患者CAG后发生CIN的简便、可靠有用的生物学标志物。

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备注/Memo

备注/Memo:
(收稿日期:2018-03-15)
(本文编辑:边 佶)
更新日期/Last Update: 2018-09-11