[1]李启洋,何 凡,曾延华,等.颅内动脉瘤用纳米电纺覆膜支架初步实验研究[J].介入放射学杂志,2016,(05):420-424.
 LI Qi- yang,HE Fan,ZENG Yan- hua,et al.Implantation of nano electro- spinning covered stent for the treatment of intracranial aneurysm: preliminary experimental study[J].journal interventional radiology,2016,(05):420-424.
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颅内动脉瘤用纳米电纺覆膜支架初步实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年05期
页码:
420-424
栏目:
实验研究
出版日期:
2016-05-25

文章信息/Info

Title:
Implantation of nano electro- spinning covered stent for the treatment of intracranial aneurysm: preliminary experimental study
作者:
李启洋 何 凡 曾延华 李 明 钟红珊 徐 克 陈旭东
Author(s):
LI Qi- yang HE Fan ZENG Yan- hua LI Ming ZHONG Hong- shan XU Ke CHEN Xu- dong
Department of Interventional Radiology, Shenzhen Municipal People’s Hospital, Second Clinical Medical College of Ji’nan University, Shenzhen, Guangdong Province 518020, China
关键词:
【关键词】 颅内动脉瘤 纳米电纺 覆膜支架 生物相容性 力学性能
文献标志码:
A
摘要:
【摘要】 目的 动物实验研究评价新型颅内动脉瘤用纳米电纺覆膜支架的力学性能和生物相容性。方法 10只健康成年比格犬中共植入20枚纳米电纺覆膜支架,其中10枚0.10 mm丝径支架植入左侧锁骨下动脉(A组),10枚0.15 mm丝径支架植入右侧锁骨下动脉(B组)。支架植入术后即刻和术后2、4、6周分别作血管造影随访。支架段血管作组织学病理检查,评价支架内皮化和内膜增生情况。结果 A组支架植入后即刻造影示7枚支架内漏,随访期间2枚支架内漏消失,5枚仍残留内漏;B组支架植入后即刻造影示1枚支架内漏,随访期间内漏消失,3枚支架发生轻度狭窄(狭窄程度<50%)。组织病理学检查显示,B组术后2周血管壁呈慢性炎性反应,术后4周支架内表面部分血管内皮化,术后6周支架内表面基本实现血管内皮化。结论 本实验研究初步证明纳米电纺覆膜支架治疗颅内动脉瘤的有效性和可行性,具有重要临床应用价值。但该支架尚处于初始研究阶段,有待进一步远期观察和研究。

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备注/Memo

备注/Memo:
(收稿日期:2015-10-15)
(本文编辑:边 佶)
更新日期/Last Update: 2016-05-16