[1]孟艳莉,黎海亮,郭晨阳,等.三氧化二砷联合经肝动脉化疗栓塞治疗多结节型或弥漫型原发性肝癌的临床研究[J].介入放射学杂志,2015,(08):680-683.
 MENG Yan-li,LI Hai-liang,GUO Chen-yang,et al.Arsenic trioxide combined with TACE for the treatment of multiple nodular or diffuse HCC: a clinical study[J].journal interventional radiology,2015,(08):680-683.
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三氧化二砷联合经肝动脉化疗栓塞治疗多结节型或弥漫型原发性肝癌的临床研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年08期
页码:
680-683
栏目:
肿瘤介入
出版日期:
2015-08-25

文章信息/Info

Title:
Arsenic trioxide combined with TACE for the treatment of multiple nodular or diffuse HCC: a clinical study
作者:
孟艳莉 黎海亮 郭晨阳 肖金成 宗登伟 胡鸿涛 骆俊朋
Author(s):
MENG Yan-li LI Hai-liang GUO Chen-yang XIAO Jin-cheng ZONG Deng-wei HU Hong-tao LUO Jun-peng
Department of Interventional Radiology, Henan Provincial Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province 450008, China
关键词:
【关键词】 原发性肝癌 砷剂 动脉内化疗栓塞
文献标志码:
A
摘要:
【摘要】 目的 探讨三氧化二砷(As2O3)联合TACE治疗多结节型或弥漫型原发性肝癌的临床效果。方法 将60例多结节型或弥漫型原发性肝癌患者随机分为两组,A组为治疗组,患者肝脏病变首次TACE后第3天开始每日给予As2O3 10 mg,静脉滴注,连续14 d,休息3周重复,后间歇给予TACE治疗。B组患者给予序贯性TACE。观察两组的近、远期疗效、介入频次、中位肿瘤无进展生存期及生活质量有无差异。结果 A组客观有效率36.7%(11/30),获益率86.7%(26/30);B组客观有效率23.3%(7/30),获益率80.0%(24/30),两组客观有效率和获益率比较差异无统计学意义,P=0.399,P=0.731。A组患者中位肿瘤无进展生存期为8.0个月(95%可信区间 5.7~10.3);B组患者中位肿瘤无进展生存期为4.0个月(95%可信区间 2.8~5.2),差异有统计学意义,P=1.37×10-6。A组患者中共行介入65次,每例平均2.2次; B组患者中共行介入111次,每例平均4.7次,两组差异具有统计学意义,P=1.38×10-4。A组30例患者中生活质量改善10例,稳定17例,降低3例; B组患者中改善7例,稳定10例,降低13例,两组差异具统计学意义,P=0.035。结论 As2O3联合TACE在多结节型或弥漫型原发性肝癌患者的应用中,可以减少TACE 的治疗次数,达到相同的疗效,提高患者的生活质量。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2014-10-08)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2015-08-23