[1]王 磊,刘福全,岳振东,等. 应用介入技术建立猪肝硬化门脉高压模型的实验研究[J].介入放射学杂志,2012,(09):756-759.
　WANG Lei,LIU Fu- quan,YUE Zhen- dong,et al. The establishment of liver cirrhosis along with portal hypertension model in experimental pigs by using interventional technique[J].journal interventional radiology,2012,(09):756-759.
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 应用介入技术建立猪肝硬化门脉高压模型的实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年09期
页码:
756-759
栏目:
实验研究
出版日期:
2012-09-30

文章信息/Info

Title:
 The establishment of liver cirrhosis along with portal hypertension model in experimental pigs by using interventional technique
作者:
 王 磊;  刘福全;  岳振东;  赵洪伟
Author(s):
 WANG Lei;  LIU Fu- quan;  YUE Zhen- dong;  ZHAO Hong- wei.
Department of Interventional Radiology， Affiliated Beijing Shijitan Hospital， Capital Medical University， Beijing 100038， China
关键词:
 ; 【关键词】 肝硬化;  介入;  门静脉高压;  动物模型
文献标志码:
A
摘要:
 【摘要】 目的 构建肝硬化动物模型并分析其病理学改变，探讨介入技术建立肝硬化模型的可行性与科学性。方法 将30头健康雄性贵州香猪分为实验组A 10头和实验组B 10头，分别采用四氯化碳腹腔注射法和肝动脉乙醇注入法构建肝硬化门脉高压症动物模型，另外10头作为对照组。结果 实验组A和实验组B成模平均时间分别为12周和6周，成模率分别为80%和100%。动物模型的门脉压力，对照组为（8.2 ± 2.3）cm水柱，实验组A为（12.4 ± 2.2） cm水柱，实验组B为（12.6 ± 2.1）cm水柱，实验组与对照组比较差异有统计学意义（P < 0.05）。结论 采用介入技术向肝动脉内灌注乙醇优于腹腔注射四氯化碳造模法，具有造模创伤小，全身损害轻、可重复性强、操作简单、病理表现及分期明显的优点，可以建立较为理想的肝硬化动物模型。

参考文献/References:

 ［1］ Madden JW， Gertman PM， Peacock EE Jr. Dimethylnitrosamine?蛳 induced hepatic cirrhosis： a new canine model of an ancient human disease［J］. Surgery， 1970， 68： 260 ?蛳 267.
［2］ Lin D， Wu X， Ji X， et al. A novel canine model of portal vein stenosis plus thioacetamide administration?蛳 induced cirrhotic por?蛳tal hypertension with hypersplenism［J］. Cell Biochem Biophys， 2012， 62： 245 ?蛳 255.
［3］ Popov Y， Sverdlov DY， Bhaskar KR， et al. Macrophage?蛳 mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary ?覱brosis［J］. Am J Physiol Gastrointest Liver Physiol， 2010， 298： G323 ?蛳 334.
［4］ Wang L， Potter JJ， Rennie?蛳 Tankersley L， et al. Effects of retinoic acid on the development of liver ?覱brosis produced by Carbon tetrachloride in mice［J］. Biochim Biophys Acta， 2007， 1772： 66 ?蛳 71.
［5］ Domenicali M， Caraceni P， Giannone F， et al. A novel model of CCl4?蛳 induced cirrhosis with ascites in the mouse［J］. J Hepatol， 2009， 51： 991 ?蛳 999.
［6］ Cameron CR，Karunaratne WAE. Carbon tetrachloride cirrhosis in relation to liver regeneration［J］. Path Bact，1936， 42： 1 ?蛳 21.
［7］ Abraldes JG， Albillos A， Ba?觡ares R， et al. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension： a randomized controlled trial［J］. Gastroenterology， 2009， 136： 1651 ?蛳 1658.
［8］ Weber SN， Wasmuth HE. Liver ?覱brosis： from animal models to mapping of human risk variants［J］. Best Pract Res Clin Gastro?蛳enterol， 2010， 24： 635 ?蛳 646.
［9］ Avritscher R， Wright KC， Javadi S， et al. Development of a large animal model of cirrhosis and portal hypertension using hepatic transarterial embolization： a study in swine［J］. J Vasc Interv Radiol， 2011， 22： 1329 ?蛳 1334.
［10］ Geerts AM， Vanheule E， Praet M， et al. Comparison of three research models of portal hypertension in mice： macroscopic， histological and portal pressure evaluation［J］. Int J Exp Pathol， 2008， 89： 251 ?蛳 263.

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 （收稿日期：２０１2-０1-1０）
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