[1]尹   达,朱 皓,周旭晨,等.血栓抽吸联合冠状动脉内注射替罗非班对心肌再灌注的影响[J].介入放射学杂志,2011,(07):522.
 YIN Da,ZHU Hao,ZHOU Xu-chen,et al.Thrombus aspiration combined with intra-coronary injection of Tirofiban for acute ST-segment elevation myocardial infarction: its influence on myocardial reperfusion[J].journal interventional radiology,2011,(07):522.
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血栓抽吸联合冠状动脉内注射替罗非班对心肌再灌注的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年07期
页码:
522
栏目:
心脏介入
出版日期:
2011-07-30

文章信息/Info

Title:
Thrombus aspiration combined with intra-coronary injection of Tirofiban for acute ST-segment elevation myocardial infarction: its influence on myocardial reperfusion
作者:
尹   达   朱 皓   周旭晨   黄榕翀 张   波   王少鹏   张佑生   贾玉卿   孙梦涵   崔哈申
116011 大连医科大学附属第一医院心内科
Author(s):
YIN Da ZHU Hao ZHOU Xu-chen HUANG Rong-chong ZHANG Bo WANG Shao-peng ZHANG You-sheng JIA Yu-qing SUN Meng-han CUI Ha-shen.
Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
关键词:
急性心肌梗死 血栓抽吸 替罗非班
分类号:
R543.31
文献标志码:
A
摘要:
目的   探讨急性ST段抬高型心肌梗死直接经皮冠状动脉介入(PCI)治疗中,血栓抽吸联合冠状动脉内注射替罗非班对心肌微循环的影响。方法 选择2008年4月至2010年6月诊断为急性ST段抬高型心肌梗死、接受直接PCI治疗患者184例,随机分为血栓抽吸联合冠状动脉内注射替罗非班组(A组,78例)和常规PCI及静脉滴注替罗非班组(B组,106例)。比较两组的临床特征、心肌梗死溶栓试验(TIMI)血流分级、心肌染色分级、术后24 h ST回落> 70%的比率、大出血发生率、住院时间及随访30 d的主要心脏不良事件。结果 与B组比较,A组的无复流发生率明显减少(21.14% 比5.67%,P = 0.011),心肌染色分级提高(1.12 ± 0.47比2.03 ± 0.32,P = 0.021),术后24 h ST回落幅度 > 70%的比率增加(85%比94%,P = 0.003),围术期大出血发生率减少(9%比4%,P = 0.03),30 d随访期间的严重不良心脏事件明显降低。结论 血栓抽吸联合冠状动脉内注射替罗非班较常规PCI能有效改善心肌微循环的再灌注,降低围手术期的风险。

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备注/Memo

备注/Memo:
收稿日期:20110327
更新日期/Last Update: 2011-07-30