[1]孟巍,曹海利,白彬,等.基质细胞衍生因子-1介入治疗股骨头坏死的实验研究[J].介入放射学杂志,2009,(04):294.
 MENG Wei,CAO Haili,BAI Bin,et al.Treatment of femoral head necrosis with transplantation of stromal cell-derived factor-1:an experimental study[J].journal interventional radiology,2009,(04):294.
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基质细胞衍生因子-1介入治疗股骨头坏死的实验研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年04期
页码:
294
栏目:
实验研究
出版日期:
2009-04-15

文章信息/Info

Title:
Treatment of femoral head necrosis with transplantation of stromal cell-derived factor-1:an experimental study
作者:
孟巍曹海利白彬
150086哈尔滨医科大学附属第二院放射介入科
Author(s):
MENG WeiCAO Hai-liBAI BinZHENG Shang-feiXU Wei
Department of Interventional Radiology,the Second Affiliated Hospital,Harbin Medical University,Harbin150086,China
关键词:
股骨头坏死缺血性基质细胞衍生因子-1髓芯减压
分类号:
R681.8
文献标志码:
B
摘要:
目的探讨基质细胞衍生因子-1(SDF-1)治疗股骨头坏死的机制和疗效。方法选用日本大耳白兔30只,制成激素性股骨头坏死模型后,随机分为3组。A组为对照组;B组为髓心减压+生理盐水治疗组;C组为髓心减压+SDF-1治疗组。各组动物均于治疗后8周处死,处死后分别进行股骨头骨密度测定及组织病理观察。结果SDF-1治疗后8周,骨密度明显增高,病理组织学表现血管数目增多,空骨陷窝减少。SDF-1治疗后显示股骨头修复效果明显。结论髓芯减压SDF-1移植治疗股骨头缺血性坏死效果明显,具有较广的临床应用前景。

参考文献/References:

[1]周强,石国华,杨柳,等.复合多孔生物材料在股骨头坏死模型中诱导成骨的观察[J].中华外科杂志,2002,40:458-461.
[2]Mont MA,Jone SLC,Einhorn TA,et al.Osteonecrosis of the femoral head.Potential treatment with growth and differentiation factors[J].Clin Orthop,1998,(355)(suppl ):314-325.
[3]M

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[2]白彬,曹海利,王凯冰,等.骨髓多能干细胞移植治疗股骨头缺血性坏死的实验研究[J].介入放射学杂志,2007,(02):122.
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备注/Memo

备注/Memo:
收稿日期:2008-11-11
基金项目:黑龙江省科学自然基金会(D200560)
更新日期/Last Update: 2009-04-15